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IN THE NEWS

June 2, 2014

Monika Weber heads Fluid-Screen, a spin-off from Reedlab. Till today the project has been honored with Grand Prizes and Financial Awards in numerous competitions.

Fluid-Screen is a portable device, which detects bacteria from fluids rapidly. In the long term, the goal is to see this very flexible and affordable technology platform, which brings a functionality of an entire microbiology lab onto a single chip, making global impact. The potential for making a difference is especially in water testing, food safety testing and medical diagnostics. Fluid-Screen is a technology with a potential to help save human lives. See specific awards for Fluid-Screen

June 24, 2013

Engineers report breakthrough in designing electronic biosensors

Biosensors are used to detect and measure toxins in the environment; in the body they can identify chemical biomarkers that signal cancer and disease states by detecting changes at the molecular level. Reed’s lab has created biosensors using silicon nanowires configured as tiny transistors that are exponentially more sensitive than current sensing technology, in addition to being cheaper and easier to use. Reed’s latest research, published in ACS Nano, outlines a method to add a layer of molecules to the surface of the biosensor that can be chemically regenerated, allowing for reuse. The ability to recharge nanodevice biosensors makes them more useful for applications like the remote monitoring of toxins or biothreats. Co-authors on the paper are Xuexin Duan, Nitin K. Rajan, David A. Routenberg and Jurriaan Huskens. Read more.

January 22, 2013

Engineers fabricate ion channels for commercial use

A team of Yale researchers has taken a fundamental cell biology concept and introduced it to the world of microchips and electronic nanotechnology. Aiming to mimic the function of ion channels embedded within cell membranes, Yale electrical engineering professor Mark Reed and Weihua Guan GRD ’14 have designed a microscopic semiconductor whose potential applications include small-scale power generation and portable desalination of ocean water. Reed and Guan most recently published their work in the January 2013 issue of Nano Letters. “The important result is that we mimic the ionic and electrostatic function of certain types of biological ion channels in an abiotic embodiment in the solid state. This could well enable many new types of microelectronic or biological interfaces,” Reed said. Read more.

August 2012

ASME podcast: Label-free nanosensors

The American Society for Mechanical Engineers released a podcast of Dr. Mark Reed explaining the basic concepts of label-free nanowire sensors. Listen here.

July 24, 2012

Graduate Student Awarded for Innovation in Primary Health Care

Monika Weber has been honored in the Ambulatory Practice of the Future “Prize for Primary Healthcare” competition.  Read more.

May 29, 2012

Protein on Wire: Nanowire Sensors Shed Light on Protein Interactions

Researchers at Yale University have shown that a method using silicon nanowires as sensors can achieve real-time kinetic results with higher sensitivity than traditional methods. Read more.

April 25, 2012

ORNL, Yale take steps toward fast, low-cost DNA sequencing device

Researchers at Oak Ridge National Laboratory and Yale University have developed a new concept for use in a high-speed genomic sequencing device that may have the potential to substantially drive down costs. "The low cost--if it can be achieved--would enable genomic sequencing to be used in everyday clinical practice for medical treatments and preventions," said Predrag Krstic, project director and former ORNL physicist now at the University of Tennessee-ORNL Joint Institute for Computational Sciences. Read more.

January 18, 2012

Diffraction lithography maps near-field light and fabricates complex nanopatterns

The lithographic patterning of complex nanostructures is essential to various emerging electronics and photonics technology. Optical lithography is consistently the method of choice thanks to its high throughput and wafer-scale reproducibility, but the diffraction limit poses a challenge as feature sizes approach the wavelength of light. Methods to circumvent this problem can be complicated and expensive. However, in recent work, researchers led by Mark Reed at Yale University, US, have shown that a novel diffraction-based optical lithography provides an opportunity for the large-area fabrication of unconventional nanostructures in a greatly simplified manner. Read more.

October 31, 2011

Yale engineers open new field of inquiry in bioelectronics

A device created by Yale University engineers could open a new field of inquiry in bioelectronics, or the merging of biological and electronic systems. Read more.

October 21, 2011

E. Coli Testing Technology From Yale Engineers Could Save Thousands Of Lives

Right now, just one in 1000 cows that pass through the deathly gates of an industrial slaughterhouse is tested for harmful pathogens. That's because the current method for testing meat costs $50 and takes 12 hours. The consequences of this languorous process speak for themselves: 5000 Americans die from food-borne illness, while 76 million others -- one in four people in the country -- fall sick. Everyone wants to blame food producers for these illnesses. But if anything, the recent spate of deadly food poisoning outbreaks highlights the huge variety of ways producers can make mistakes in food safety. It would be virtually impossible to eliminate infection from the food system altogether. The best solution, instead, may be to find a better way to test our food -- and a group of graduate students at the Yale School of Engineering and Applied Sciences thinks they've found the answer. These budding engineers, led by Monika Weber and supervised by engineering Professor Mark Reed, have developed a design for a device that would cut the cost of testing down to $1, and the time it would take to test a sample down to 30 minutes. The design, which they call the α-screen (pronounced "alpha-screen") uses nanotechnology to detect the presence of bacteria so quickly and accurately that Weber says it may one day allow meat producers to incorporate bacterial testing into the production line and test every single cow that goes to market. Read more.

October 4, 2011

Yale engineers win design competition for bacteria screen

Members of the Yale School of Engineering and Applied Science (SEAS) have received the grand prize in a national competition for their design of a new way to both detect bacteria that cause food-borne diseases and help doctors diagnose infections. Read more.

May 23, 2011

Particle Trap Paves Way for Personalized Medicine

A team led by Yale University researchers has proven that isolating individual charged particles is indeed possible using a method called "Paul trapping," which uses oscillating electric fields to confine the particles to a space only nanometers in size. Until now, scientists have only been able to use Paul traps for particles in a vacuum, but the Yale team was able to confine a charged test particle — in this case, a polystyrene bead — to an accuracy of just 10 nanometers in aqueous solutions between quadruple microelectrodes that supplied the electric field. Read more.

December 24, 2009

First Functional Molecular Transistor Comes Alive

Researchers showed the first functional transistor made from a single molecule. The transistor, which has a benzene molecule attached to gold contacts, could behave just like a silicon transistor. The molecule’s different energy states can be manipulated by varying the voltage applied to it through the contacts. And by manipulating the energy states, researchers were able to control the current passing through it… molecular transistors could escalate the next step of developing nanomachines that would take just a few atoms to perform complex calculations, enabling massive parallel computers to be built. The team, which includes researchers from Yale University and the Gwangju Institute of Science and Technology in South Korea, published their findings in the Dec. 24 issue of the journal Nature. Read more.

December 13, 2009

Scientists Use Nanosensors for First Time to Measure Cancer Biomarkers in Blood

A team led by Yale University researchers has used nanosensors to measure cancer biomarkers in whole blood for the first time. Their findings, which appear December 13 in the advanced online publication of Nature Nanotechnology, could dramatically simplify the way physicians test for biomarkers of cancer and other diseases. The team—led by Mark Reed, Yale's Harold Hodgkinson Professor of Engineering & Applied Science, and Tarek Fahmy, an associate professor of biomedical and chemical engineering—used nanowire sensors to detect and measure concentrations of two specific biomarkers: one for prostate cancer and the other for breast cancer. Read more.

November 18, 2008

Yale’s Reed Honored for Outstanding Nanotechnology Research

Yale Professor Mark Reed, whose research has contributed to nanotechnology in areas from quantum dots to molecular electronics, has been named a fellow of the IEEE, one of the most prestigious honors given by this professional association for the advancement of technology. Read more.

January 31, 2007

Breakthrough in Nanodevice Synthesis Revolutionizes Biological Sensors

Now researchers at Yale University have developed ultrasensitive nanoscale sensors that are easy to manufacture. The sensors are based on semiconducting nanowires, which can detect single virus particles or ultra-low concentrations of a targeted substance, as other researchers have already shown…. In experiments described in this week’s issue of the journal Nature, the sensors were used to detect a variety of things, including specific antibodies. The nanowires are first spotted with molecules designed to bind to the target antibody; when the target is present and the link is made, it causes the conductivity in the nanowire to change, creating a readable signal. Since the body’s immune system produces minute amounts of antibodies in response to diseases such as cancer, the devices could be used for early diagnoses. Read more.

January 31, 2007

Easy-to-Make Nanosensors: Tiny electronics-based detectors could provide simple tests for cancer or bioterror agents

A novel approach to synthesizing nanowires (NWs) allows their direct integration with microelectronic systems for the first time, as well as their ability to act as highly sensitive biomolecule detectors that could revolutionize biological diagnostic applications, according to a report in Nature. Read more.

Mark A. Reed Group