Our research is focused on single-cell analysis of human diseases to help transform the future medicine: we look to exploit systems biology principles to develop micro and nano scale biotechnologies for differential diagnosis and personalized treatment. In particular we are thriving to develop informative single cell proteomic and functional genomics technologies via integrating high-density microarray and microfluidics in order to interrogate small numbers of cells from clinical specimens. We also compliment these technologies with models that advance our understanding of various biological systems and diseases. We are currently interested in how chronic inflammation plays a critical role in the pathogenesis of various complex human diseases including neurodegenerative disease, cardiovascular disease and cancer.
Current research topics include (1) tumor microenvironment and systems oncology, (2) cellular immunity and informative immune monitoring, (3) vascular inflammation and heart disease, and (4) stem cell biology and engineering.