• New Single-Cell Measurement Techniques Reveal Significant Functional Heterogeneity



Our group is focused on exploiting systems biology principles to develop single cell micro/nano-technologies for comprehensive analysis of cellular heterogeneity in human health and disease. The goal is to transform diagnosis and therapy of complex human diseases including cancer, infectious and autoimmune diseases to enable personalized medicine.

One post-baccalaureate research assistant position is open in Fan lab and the project involves the use of single-cell proteomic, transcriptomic, and/or epigenomic analyses to study tumor-immune interaction and monitor immunotherapy.

One postdoctoral associate position will be open in 2019 and the project is relating to cancer immunobiology and immunotherapy. Candidates with expertise in experimental cancer biology, T cell biology, cell-based immunotherapy are strongly encouraged to apply.

Our laboratory is located at the Malone Engineering Center of Yale main campus and the lab has long standing collaborations with researchers from Yale School of Medicine, Memorial Sloan Kettering Cancer Center, and University of Pennsylvania School of Medicine, and Dana Farber Cancer Center to apply our technologies to clinical studies. We encourage candidates who are highly motivated, collaborative, and passionate about translational research to apply.

Should you be interested, please contact Prof. Fan directly via email (rong.fan at yale.edu) with your CV attached.

11-12-2018

Rong Fan, Ph. D

Associate Professor 
Department of Biomedical Engineering 
Yale University 
E.mail: rong (dot) fan (at) yale (dot) edu
Phone: 203-432-9905

Address: Malone Engineering Center
              55 Prospect St. New Haven, CT 06511
Prof. Fan Office: MEC 213
Lab:  MEC 103 
Student office: MEC 103 B, C

Dr. Rong Fan is Associate Professor of Biomedical Engineering at Yale University. He received a B.S. in Applied Chemistry from University of Science and Technology in China, a Ph.D. in Chemistry from the University of California at Berkeley, and then completed his postdoctoral training at California Institute of Technology, prior to starting his own research laboratory at Yale University in 2010. His current research interest is centered on developing single-cell technologies to interrogate functional cellular heterogeneity and inter-cellular signaling network in human health and disease (e.g., cancer and autoimmunity). He developed a microchip technology that, for the first time, permits simultaneous measurement of 42 immune effector proteins in single cells, representing the highest multiplexing to date for a single-cell protein secretion assay. He also develops high-throughput technologies for co-analysis of single-cell epigenomic, transcriptomic, and proteomic profiles. These technologies have been applied to the study of human hematopoietic malignancies, brain cancer, lung cancer, and autoimmune diseases, for early diagnosis, patient stratification, and precision medicine. He co-founded IsoPlexis to commercialize single-cell high-plex cytokine measurement device, which has been widely used by pharmaceutical companies and clinical trial centers to evaluate cancer immunotherapy products. He co-founded Singleron Biotechnologies that aims to bring single-cell sequencing to distributed clinical test applications. He also serves on Scientific Advisory Board (SAB) of Bio-Techne. Dr. Fan is the recipient of numerous awards including the NCI Howard Temin Career Transition Award, the NSF CAREER Award, and the Packard Fellowship for Science and Engineering.

Our research is currently supported by the National Institutes of Health Common Fund Program, National Cancer Institute PS-OC Program and the IMAT Program, the NIDDK Fibrosis Consortium, the National Science Foundation, and the David & Lucile Packard Foundation.

 

Funding Sources

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