New Single-Cell Measurement Techniques
Reveal Significant Functional Heterogeneity
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Rong Fan

Associate Professor
Department of Biomedical Engineering Yale University
E.mail: rong (dot) fan (at) yale (dot) edu
Phone: 203-432-9905


Dr. Rong Fan is Associate Professor of Biomedical Engineering at Yale University. He received a B.S. in Applied Chemistry from University of Science and Technology in China, a Ph.D. in Chemistry from the University of California at Berkeley, and then completed his postdoctoral training at California Institute of Technology, prior to starting his own research laboratory at Yale University in 2010. His current research interest is centered on developing single-cell technologies to interrogate functional cellular heterogeneity and inter-cellular signaling network in human health and disease (e.g., cancer and autoimmunity). He developed a microchip technology that, for the first time, permits simultaneous measurement of 42 immune effector proteins in single cells, representing the highest multiplexing to date for a single-cell protein secretion assay. He also develops high-throughput technologies for co-analysis of single-cell epigenomic, transcriptomic, and proteomic profiles. These technologies have been applied to the study of human hematopoietic malignancies, brain cancer, lung cancer, and autoimmune diseases, for early diagnosis, patient stratification, and precision medicine. He co-founded IsoPlexis to commercialize single-cell high-plex cytokine measurement device, which has been widely used by pharmaceutical companies and clinical trial centers to evaluate cancer immunotherapy products. He co-founded Singleron Biotechnologies that aims to bring single-cell sequencing to distributed clinical test applications. He also serves on Scientific Advisory Board (SAB) of Bio-Techne. Dr. Fan is the recipient of numerous awards including the NCI Howard Temin Career Transition Award, the NSF CAREER Award, and the Packard Fellowship for Science and Engineering.

Funding Scources

Our research is currently supported by the National Institutes of Health Common Fund Program, National Cancer Institute PS-OC Program and the IMAT Program, the NIDDK Fibrosis Consortium, the National Science Foundation, and the David & Lucile Packard Foundation.