The Laboratory of
David A. LaVan, P.E., Ph.D.
My laboratory at Yale University works in several
areas related to the characterization, development, and evaluation of materials
and devices for use in microsystems (and nano and macro systems), with particular
interest in biomedical applications.
I am the Director of the Mechanical Engineering Design
Program and teach Machine Design and Forensic Engineering. Forensic Engineering is based on my personal
experiences consulting and performing failure analysis for a variety of
clients.
I am a member of Yale's Interdepartmental Neuroscience
Program (INP) and The
Combined Program in the Biological & Biomedical Sciences (BBS).
The P.E. after my name signifies that I am a
registered professional
engineer.
I received a B.S. in Materials Science from the
University of Florida in 1991, a M.S. in Mechanical Engineering from the
University of Florida in 1994 working with Ali Seireg,
and a Ph.D. in Mechanical Engineering from The Johns Hopkins University in 1998 working with
William N. Sharpe, Jr. I have worked as
an engineer, in technical consulting, as a post doc and staff at Sandia
National Laboratory, and as a research fellow in Robert Langer's lab at MIT and
Harvard-Children's Hospital before joining Yale in 2003.
Contact info:
Yale
University
Department
of Mechanical Engineering
9
Hillhouse Avenue
Mason
Labs, Room M3
New
Haven, CT 06511
203.432.9662
f a x 203.432.7654
david.lavan(at)yale.edu
Recent Publications:
Yu Xiang and David A. LaVan
"Analysis of soft cantilevers as force transducers" Applied Physics Letters, in-press (2007)
Eric Stern, James Klemic
, David Routenberg , Pauline Wyrembak
, Daniel Turner-Evans , Andy Hamilton , David LaVan, Tarek Fahmy, Mark Reed
"Label-Free Detection of DNA, Protein, and Cellular Response with
CMOS-Compatible Semiconducting Nanowire Sensors"
Nature 445:519-522 (2007).
David A. LaVan and Jennifer
N. Cha "Approaches for Biological and Biomimetic Energy Conversion" Proceedings of the National Academy of Sciences (PNAS)
103:5251-5255 (2006).
Kunisaki SM, Fuchs JR, Kaviani A, Oh JT, LaVan DA, Vacanti JP, Wilson JM, Fauza DO
"Diaphragmatic repair through fetal tissue engineering: a comparison
between mesenchymal amniocyte-
and myoblast-based constructs" J. Peiatric
Surgery 41 (1): 34-39 (2006)
Eric Stern, Steven Jay, James Bertram,
Benjamin Boese, Ilona Kretzschmar,
Daniel Turner-Evans, Carl Dietz, Alec Flyer, Pauline Wyrembak,
Elnaz Menhaji, David A. LaVan, Tadeusz Malinski, Tarek Fahmy, Mark A. Reed "Selective Functionalization of
Microelectrodes" Analytical Chemistry 78:6340-6346 (2006).
Paul M. George, David A.
LaVan, Jason A. Burdick, Ching-Yuan Chen,
Ellen Liang, Robert Langer "Electrically
Controlled Drug Delivery from Biotin-Doped Conductive Polypyrrole" Advanced Materials 18(5):577-581 (2006)
Paul George, Alvin Lyckman, David A. LaVan, Yuika Leung,
Anita Hegde, Rupali Avasare, Chris Testa, Phillip
Alexander, Robert Langer, Mriganka Sur "Fabrication of polypyrrole implants as potential
substrates for neural prosthetics" Biomaterials
26:3511-3519 (2005).
-
- David
A. LaVan, Robert F. Padera, Thomas A. Friedmann, John P. Sullivan, Robert
Langer, Daniel S. Kohane, “In Vivo evaluation of tetrahedral amorphous carbon.” Biomaterials 26: 465-473 (2005). click here
- Benjamin D. Matthews, David A. LaVan,
Darryl R. Overby, John Karavitis
and Donald E. Ingber "Electromagnetic needles
with 100nm pole tip radii for manipulation of biomolecules and living
cells" Applied Physics Letters
85(14): 2968-2970 (2004). click here
- Fuchs
JR, Kaviani A, Oh JT, LaVan D,
Udagawa T, Jennings RW, Wilson JM, Fauza DO “Diaphragmatic reconstruction with autologous tendon engineered from mesenchymal
amniocytes J.
Pediatric Surgery 39 (6): 834-837 2004
- David A. LaVan,
Terry McGuire and Robert Langer “Small Scale Systems for in vivo drug delivery”
Nature Biotechnology 21 1184 -1191 (2003). click here
- David A.
LaVan, Paul M. George, Robert Langer, “Simple, three-dimensional
microfabrication of electrodeposited structures” Angewandte
Chemie Int’l Ed. 11 1262-1265 (2003).
click here or click here
- Buchheit TE, Glass SJ, Sullivan JR, Mani SS, LaVan DA,
Friedmann TA, Janek R, “Micromechanical testing of
MEMS materials” J. Matls. Sci.
38 (20): 4081-4086 OCT 15 2003
-
Buchheit TE, LaVan DA,
Michael JR, Leith SD “Microstructural
and Mechanical Properties Investigation of Electrodeposited and Annealed LIGA
Nickel Structures” Metallurgical and Materials Transactions, 33A 539-554 (March 2002). click here or click here
- David A.
LaVan, David Lynn, and Robert Langer, “Moving Smaller in Drug
Discovery and Delivery” Nature Reviews Drug Discovery 1 77-84 (2002). click here
-
Jensen, Brian D., Maarten P. de Boer, Nathan
D. Masters, Fernando Bitsie, and David A. LaVan “Interferometry
of Actuated Microcantilevers to Determine Material
Properties and Test Structure Nonidealities in MEMS”
J. Micro-Electro-Mech Syst.
3 336-346 (2001). click here or
click here or click here
-
David A. LaVan and Robert
Langer, “Implications of Nanotechnology in the Pharmaceutics and Medical
Fields” National Science Foundation Report on Societal Implications of
Nanoscience and Nanotechnology, 79-82 (2001). click here
- D. A. LaVan, K. Jackson, B. McKenzie, S.J.
Glass, T.A. Friedmann, J.P. Sullivan, and T. E. Buchheit, “Direct Tension and
Fracture Toughness Testing Using the Lateral Force Capabilities of a Nanomechanical Test System” ASTM STP 1413 Mechanical
Properties of Structural Films, West Conshohocken, PA, 2001, pp.
16-27. click here
-
D. A. LaVan, T. Tsuchiya,
G. Coles, W.G. Knauss, I. Chasiotis,
and D. Read. “Cross Comparison of Direct Tensile Testing Techniques on SUMMiT Polysilicon Films” ASTM STP 1413 Mechanical
Properties of Structural Films, West Conshohocken, PA, 2001, pp.
62-71. click here
- LaVan
DA, Sharpe WN Local properties of undermatched
steel weld metal METALLURGICAL AND MATERIALS TRANSACTIONS A-32 (4):
913-922 APR 2001
- Yunfeng Lu, Hongyou Fan, Nilesh Doke, Douglas A. Loy,
Roger A. Assink, David
A. LaVan, and C. Jeffrey Brinker.
“Evaporation-Induced Self-Assembly of Hybrid Bridged Silsesquioxane
Film and Particulate Mesophases with Integral Organic
Functionality.” J. Am. Chem. Soc. 122
5258-5261 (2000). click here or click here
- Noe DC, LaVan DA, Veblen
D Lap shear testing of biotite and phlogopite crystals and the application of interferometric
strain/displacement gages to mineralogy JOURNAL OF GEOPHYSICAL
RESEARCH-SOLID EARTH 104 (B8): 17811-17822 AUG 10 1999
- LaVan DA, Sharpe WN Tensile testing of microsamples EXPERIMENTAL
MECHANICS 39 (3): 210-216 SEP 1999
Classes Taught
ME185 – Introduction to Mechanical Design
ME489 – Mechanical Design
ME 386 Forensic Engineering
E&AS 996 – Design Synthesis
My ISI statistics (ISI does not index all my papers)
August 2004: 12
papers indexed 166 total citations
April 2005: 17 papers indexed 230
total citations
November 2005: 17
papers indexed 293 total citations
February 2007: 23 papers indexed 469
total citations
Edited Proceedings:
Cengiz S. Ozkan, David A. LaVan, Mark McNie, Somuri Prasad. Micro- and Nanosystems-Materials and Devices. Vol 872 Materials Research Society, 2005
David
A. LaVan, Arturo Ayon, Marc Madou, Mark McNie, Somuri Prasad. Micro- and Nanosystems. Vol 782 Materials Research Society, 2004
David A. LaVan,
Arturo Ayon, Thomas Buchheit, Marc Madou, Nano-
and Microelectromechanical Systems (NEMS and MEMS) and Molecular Machines. Vol 741 Materials
Research Society, 2003
Invited Presentations:
10/18/2005 Biomaterials Symposium, American College of Surgeons
Meeting
8/30/2005 Combinatorial Materials Symposium, American Chemical
Society Meeting
3/27/2005 BioMEMS Tutorial, MRS Spring Meeting
1/24/2003 Dept. of Mechanical, Industrial and Manufacturing Eng.,
Northeastern University
11/21/2002 MEMS Evaluation ASME Int’l Mechanical Engineering
Congress
4/6/2002 MRS MEMS Workshop
10/30/2001 Lake Louise Composites Conference
7/23/2001 National Health Council, Frontiers of Health Lecture,
House Rayburn Office Building
10/26/2000 California Institute of Technology, Dept. of
Aeronautical Engineering
8/22/2000 Los
Alamos National Laboratories, Materials Center
03/23/2000 Georgia Institute of
Technology, Dept. of Mechanical Engineering