Analytical biotechnology. Application of high performance liquid chromatography, capillary electrophoresis and mass spectrometry to characterization of biological macromolecules, such as in the study of the human Genome and the corresponding protein products (the Proteome). 

Selected Publications:

 

"Investigation of the potential of capillary electrophoresis (CE) with off-line matrix assisted laser desorption ionization time of flight (MALDI-TOF) mass spectrometry for clinical analysis: Examination of a peptidoglycan factor associated with cancer cachexia," G. Choudhary, J. Chakel, W. Hancock, A. Torres-Duarte, G. McMahon, I. Wainer, Anal. Chem., 71,  855-859 (1999).

 

"The Effect of Electric Field on LC Separation of Peptide Digests: Combining Capillary Separation Techniques," A. Apffel, H.Yin, W.S. Hancock, D. McManigill, J. Frenz, S-L.Wu, J. Chromatogr., 832, 149-163 (1999).

 

"The Use of Multidimensional Liquid Phase Separations and Mass Spectrometry for the DetailedCharacterization of Post-translational Modifications in Proteins," S. Udiavar, A. Apffel, J. Chakel, S. Swedberg, W.S. Hancock, and E. Pungor, Anal. Chem., 70, 3572-3578 (1998).

 

"A rapid and sensitive procedure for the micro-purification and subsequent characterization of peptides and protein samples by N-terminal sequencing and matrix assisted laser desorption ionization time of flight mass spectrometry," R.Grimm, K.D. Grasser,  J. Kubach, and W.S. Hancock, J. Pharm. Biomed. Anal., 18, 545-554 (1998).