Biomaterials Working Group

at Yale University

The Biomaterials Working Group was founded to connect researchers and resources within the many disciplines at Yale that are working on the Synthesis, Characterization, Analysis, Application and Modeling of biomaterials.

People

Paul Van Tassel, Group Organizer

Shared resources available at Yale

(please submit additional entries)

Facilities in Yale’s Geology Department

Environmental Field Emission SEM with XDS (Geology)

ICP-MS (Geology)

Microprobe (Geology)

Confocal (Med School)

Protein Chemistry (HPLC, Electospray, MALDI, etc) (Med School)

Proteomics (Med School)

Dynamic Light Scattering, Isothermal Calorimeter (Med School)

TEM

MALDI

Peptide Synthesis (Med School) – Large Scale or Small Scale

DNA Synthesis

NMR

Chemistry Department Stockroom

Chemistry Department Instrument Center

Chemistry Department Student Machine Shop

J.W. Gibbs Building Machine Shop

STM, XPS, FTIR, LEED, Auger

Equipment within labs of group members

(please submit additional entries)

(this equipment may not be freely available):

Prep scale HPLC (Lavik/LaVan/Mitch)

Schlenk line (LaVan)

Sieve shaker (LaVan)

Plasma cleaner (LaVan)

Spectro/Fluorometer (LaVan)

Soft Tissue Tensile Tester (LaVan)

Fluorescent plate reader (Lavik)

Polymer Microfabrication (Hur/LaVan)

Optical Waveguide Lightguide Spectroscopy (OWLS) (Van Tassel)

Quartz Crystal Microbalance (Van Tassel)

Atomic Force Microscope

Fluorescent Microscopes (Van Tassel, Lavik, LaVan)

Courses (with a strong biomaterials component)

BENG 434b Biomaterials

BENG 464a Tissue Engineering

BENG 457b Biomechanics

Seminars

Fall 2004

All seminars will take place at noon in Mason Lab Building. The room is TBA

Sept. 10:

Paul Van Tassel

"Multilayer protein assemblies as biomaterial coatings"

Oct. 8:

David LaVan

"Microfabrication to manipulate and investigate the biological world"

Nov. 12

Mark Saltzman

"Biomaterials for controlled release of proteins"

Dec. 10:

Ann Valentine

"Possible titanium biomaterials in marine organisms"

Biomaterials publications from group members:

"Fibronectin adsorption onto polyelectrolyte multilayer films", A. P. Ngankam, G. Mao, and P. R. Van Tassel, Langmuir, 2004, 20, 3362.

"Protein adsorption: kinetics and history dependence", Y. Tie, C. Calonder, and P. R. Van Tassel, Journal of Colloid and Interface Science, 2003, 268, 1.

"Biomolecules at interfaces", P. R. Van Tassel, Encyclopedia of Polymer Science and Technology, 3rd Edition (Wiley), 2003, 5, 285.

"Protein adsorption under an applied electric field using optical waveguide lightmode spectroscopy", M. A. Brusatori, Y. Tie, and P. R. Van Tassel, Langmuir, 2003, 19, 5089.

"Biosensing under an applied voltage using optical waveguide lightmode spectroscopy", M. A. Brusatori and P. R. Van Tassel, Biosensors and Biolectronics, 2003, 18, 1269.

“Stabilized polyglycolic acid fiber-based tubes for tissue engineering.” Mooney DJ, Mazzoni CL, Breuer CK, McNamara K, Hern D, Vacanti JP, Langer R. Biomaterials. 1996, 17(2):115-24.

“'Tissue Engineering Lamb Heart Valve Leaflets.” Breuer CK, Shin'oka T, Tanel RE, Zund G, Mooney DJ, Ma PX, Miura T, Colan S, Langer R, Mayer JE, and Vacanti JP. Biotechnology and Bioengineering. 1996, 50:562-567.

“The in vitro construction of a tissue engineered bioprosthetic heart valve.” Zund G, Breuer CK, Shinoka T, Ma PX, Langer R, Mayer JE, Vacanti JP. European Journal of Cardio-Thoracic Surgery. 1997, 11(3):493-7.

“Small Scale Systems for in vivo drug delivery” David A. LaVan, Terry McGuire and Robert Langer, Nature Biotechnology 21 1184 –1191 (2003).

“Simple, three-dimensional microfabrication of electrodeposited structures” David A. LaVan, Paul M. George, Robert Langer, Angewandte Chemie Int’l Ed. 11 1262-1265 (2003).

“Moving Smaller in Drug Discovery and Delivery” David A. LaVan, David Lynn, and Robert Langer, Nature Reviews Drug Discovery 1 77-84 (2002).

“In vivo evaluation of tetrahedral amorphous carbon” David A. LaVan, Robert F. Padera, Thomas A. Friedmann, John P. Sullivan, Robert Langer and Daniel S. Kohane Biomaterials, Volume 26, Issue 5, February 2005, Pages 465-473

Noe, D. C.; Veblen, D.; LaVan, D. A. Lap shear testing of biotite and phlogopite crystals and the application of interferometric strain/displacement gages to mineralogy, Journal of Geophysical Research - Solid Earth, 1999, V 104, N. 8

"Engineering Three-Dimensional Tissue Structures Using Differentiating Human Embryonic Stem Cells," S. Levenberg, N.F. Huang, E.B. Lavik, A. Rogers, J. Itskovitz-Eldor, and R. Langer, PNAS (in press 2003).

"Functional Recovery Following Traumatic Spinal Cord Injury Mediated by a Unique Polymer Scaffold Seeded with Neural Stem Cells," Y.D. Teng, E.B. Lavik, X. Qu, K.I. Park, J. Ourednik, D. Zurakowski, R. Langer, E.Y. Snyder, Proc. Nat. Acad. Sci., 99, 3024-3029 (2002).

"A Simple Synthetic Route to the Formation of a Block Copolymer of Poly (lactic-co-glycolic acid) and Polylysine for the J.S. Hrkach, N. Lotan, R. Nazarov, R.J. Langer, Biomed. Mat. Res., 58, 291-294 (2001)

"Building drug delivery into tissue engineering," W.M. Saltzman and W.L. Olbricht, Nature Reviews Drug Discovery, 1, 177-186 (2002).

"Poly(ethylene glycol)-conjugated dendrimer for biocompatible, high efficient, and low cost DNA delivery," D. Luo, K. Haverstick, N. Belcheva, E. Han, and W.M. Saltzman, Macromolecules, 35, 3456-3462 (2002).

"Micron-scale positioning of features influences the rate of polymorphonuclear leukocyte migration," J. Tan, H. Shen, and W.M. Saltzman, Biophysical Journal, 81, 2569-2579 (2001).

"Transplantation of brain cells assembled around a programmable, synthetic microenvironment," M.J. Mahoney and W.M. Saltzman, Nature Biotechnology, 19, 934-938 (2001).

Schechner, J.S., and I.M. Braverman. 1992. Synchronous vasomotion in the human cutaneous microvasculature provides evidence for central modulation. Microvasc Res 44, no. 1:27-32.

Karmann, K., C.C. Hughes, J. Schechner, W.C. Fanslow, and J.S. Pober. 1995. CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc Natl Acad Sci U S A 92, no. 10:4342-6.

Eldred, W.D., J. Ammermuller, J. Schechner, U.D. Behrens, and R. Weiler. 1996. Quantitative anatomy, synaptic connectivity and physiology of amacrine cells with glucagon-like immunoreactivity in the turtle retina. J Neurocytol 25, no. 5:347-64.

Sultan, P., J.S. Schechner, J.M. McNIff, P.S. Hochman, C.W. Hughes, M.I. Lorber, P.W. Askenase, and J.S. Pober. 1997. Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse /human chimeras. Nature Biotech 15:759-762.

Skinner, H.C.W. and Berger, A., Editors(2003) GEOLOGY AND HEALTH, CLOSING THE GAP Oxford University Press, New York. 204 pages

Gaines, R. Skinner, H.C.W., Foord, E., Mason, and Rosensweig, A., Editors (1997) DANA'S NEW MINERALOGY John Wiley and Sons 1900 pages

"Skinner, H.C.W. (2000) ""Minerals and human health"". p.383-412 In Environmental Mineralogy. Edited by D.J.Vaughan & R.A. Wogelius, Eotvos University Press.

"Skinner, H.C.W. and Fitzpatrick, R. ,Editors (1992) Biomineralization, Processes of Iron and Manganese :Modern and Ancient Environments. CATENA VERLAG, Cremlingen,-Destedt, Germany Sup 2321 434 pages.

European Mineralogical Union Notes in Mineralogy.""Skinner, H.C.W. (2000) ""In prasie of phosphates, or why vertebrates chose apatite to mineralze their skeletal elements"". International Geology Review 42: 232-240."

Smoukov, S.; Kopp, D. A.; Valentine, A. M.; Davydov, R.; Lippard, S. J.; Hoffman, B. M. “Product Binding to the Diiron(III) and Mixed-Valence Diiron Centers of Methane Monooxygenase Hydroxylase Studied by ^1,2H and ¹⁹F ENDOR Spectroscopy” J. Am. Chem. Soc., 2002, 124, 2657-2663.

Valentine, A. M.; Stahl, S. S.; Lippard, S. J. "Mechanistic Studies of the Reaction of Reduced Methane Monooxygenase Hydroxylase with Dioxygen and Substrates" J. Am. Chem. Soc., 1999, 121, 3876-3887

Valentine, A. M.; Ishmael, F. T.; Shier, V. K.; Benkovic, S. J. “A Zinc Ribbon Protein in DNA Replication: Primer Synthesis and Macromolecular Interactions by the Bacteriophage T4 Primase” Biochemistry, 2001, 40, 15074-15085.

Benkovic, S. J.; Valentine A. M. “Enzyme Kinetics” in Encyclopedia of Physical Science and Technology, 3^rd ed., vol. 5, R. A. Meyers, ed., New York: Academic Press, 2001.

Webmaster: David LaVan